Mastering Mast Cell Activation & Histamine Intolerance: A Clinician’s Deep Dive into MCAS
Course Description
This in-depth professional training is designed for clinicians, naturopathic doctors, functional medicine practitioners, and allied health providers looking to master the clinical, diagnostic, and therapeutic complexities of Mast Cell Activation Syndrome (MCAS), histamine intolerance, and related immune dysregulation syndromes.
Drawing on the latest 2025 research, robust clinical experience, and real-world case studies, this course provides a rigorous yet practical approach to understanding how mast cells and histamine interact with nearly every system of the body. You’ll leave equipped to recognize nuanced symptom presentations, interpret the confusing world of labs and biomarkers, apply evidence-informed treatment strategies, and better support patients who’ve been left undiagnosed or misdiagnosed.
Whether you’re new to this terrain or experienced but seeking updated frameworks, this course offers a complete re-education.
Participants will learn to:
- Differentiate MCAS from mastocytosis, histamine intolerance, and common allergic conditions
- Identify the wide-reaching symptom patterns tied to mast cell dysregulation across bodily systems
- Understand histamine metabolism, receptor pathways (H1–H4), and enzyme activity (DAO & HNMT)
- Interpret key diagnostic tests: serum tryptase, urinary methyl-histamine, prostaglandins, and beyond
- Apply international consensus criteria and diagnostic algorithms for MCAS
- Design layered treatment protocols using diet, pharmaceuticals, nutraceuticals, and lifestyle strategies
- Integrate insights from genetics, microbiome science, and hormone health into clinical care
- Manage challenging, refractory, or sensitive patients through advanced case mapping
Educate and advocate for patients navigating a misunderstood and under-recognized syndrome
MCAS is under-diagnosed, misunderstood, and often debilitating. Many of your most complex patients — with diagnoses like IBS, anxiety, chronic fatigue, dermatographism, interstitial cystitis, and migraine — may actually be living with an unrecognized mast cell disorder.
This course helps you see the full picture, empower your patients, and provide validation through clarity
